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Displaying: 21 - 30 of 103 Results
Studying interactions between essential bacterial ABC (ATP-binding cassette) transporter MsbA and bacterial LPS to pave the way for new antibiotic discovery
Gram-negative bacteria cause multiple infectious disease and are increasingly becoming resistant to antibiotics. However, development of drugs targeting these organisms is complicated by the extreme complexity of the structure of gram-negative cell…
DBD
- Grant Zimmermann
Investigators
- Maofu Liao
3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…
DBD
- Yelena Bisharyan
Investigators
- Paola Arlotta
- Giorgia Quadrato
FlicR: A bright and fast red fluorescent protein voltage indicator that reports neuronal activity
Fluorescent-protein-based voltage indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution. FlicR is a new bright red fluorescent protein-based voltage indicator that has…
DBD
- Yelena Bisharyan
Investigators
- Adam Cohen
Using evolutionary coupling methodology and other unique computational biology tools to advance pharmaceutical development
The prediction of drug effects is a long-standing challenge in the biomedical data community and pharmaceutical industry. As new candidate target genes emerge from successful CRISPR and GWAS screens, assessing ‘anti-targets’ and exploiting…
DBD
- Irit Ben-Chelouche
Investigators
- Debora Marks
Spin-Lock Induced Crossing (SLIC) pulse sequence for NMR spectroscopy and imaging
Nuclear magnetic resonance (NMR) spectroscopy is an important tool for determining the chemical structure of molecules, and it is used extensively for biomedical research and drug discovery. However, in many samples the frequency signatures of…
Investigators
- Ronald Walsworth
- Stephen DeVience
- Matthew Rosen
Liquid biopsy-based predictive platform for early cancer detection and drug discovery
Recognition and management of individuals susceptible to disease are critical for patient care. However, identification of these patients is very challenging, especially in oncology. Dr. Peter Park and his group at the Department of Biomedical…
DBD
- Irit Ben-Chelouche
Investigators
- Peter Park
A novel and effective technology for target-based screening
Target-based screening allows for rapid identification of ligands for an increasing number of macromolecular targets and is commonly used in drug discovery.The present invention uses interaction-dependent PCR (IDPCR) to selectively identify…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Christoph Dumelin
- David Gorin
- Lynn McGregor
Highly specific chemical detection using NMR at low magnetic fields
NMR often does not have sufficient resolution to distinguish between chemicals with related or similar structures in the presence of a large background, which leads to poor chemical specificity. The NMR spectra of complex chemical mixtures may…
Investigators
- Ronald Walsworth
- Matthew Rosen
- Stephen DeVience
Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics
Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…
DBD
- Yelena Bisharyan
Investigators
- Adam Cohen
- Miao-Ping Chien
Enhancers of Gene Therapy
Currently available gene therapy technologies rely on either plasmid DNA or viral vector transduction to enable gene transfer. However, such methods often suffer from poor direct expression and insufficient incorporation of foreign genetic material.…
DBD
- Vivian Berlin
Investigators
- David Knipe
- Megan Orzalli