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Displaying: 61 - 70 of 103 Results
Using (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage
• ILV can be used alone, or in combination with growth factors, to direct differentiation of ESCs into pancreatic specification. ILV is effective on human ESC lines and mouse ESC lines. • ILV is effective on human ESC lines HUES 2, 4 and 8. After 4…
DBD
- Vivian Berlin
Investigators
- Douglas Melton
- Shuibing Chen
- Malgorzata Borowiak
- Julia Fox
- Stuart Schreiber
- Lee Peng
- Lee Rubin
- Kelvin Lam
- Lance Davidow
New cell sorting technology could replace fluorescent and magnetic technologies
Dr. Prentiss’ lab has developed a new cell sorting technology based on microfluidics. This technique enables manipulation of non-magnetic micro- and nano-entities, including cells, immersed in magnetic fluids. Compared to existing MACS and FACS cell…
DBD
- Sam Liss
Investigators
- Mara Prentiss
- Pierre Striehl
- Howard Stone
- Efraim Feinstein
Vertical silicon nanowires as a universal platform for highly efficient delivery of bioactive molecules into living cells
This platform consists of an array of surface-modified vertical silicon nanowires that have been chemically grown or etched on a wafer and to which virtually any kind of bioactive species (drug, protein, nucleic acid, nanoparticles) may be attached…
DBD
- Christopher Petty
Investigators
- Hongkun Park
- EunGyeong Yang
- JinSeok Lee
- Alexander Shalek
- Myung-Han Yoon
- Jacob Robinson
- Amy Sutton
- Marsela Jorgolli
Paper-supported 3D cell culture for cell and tissue-based bioassays
In this new approach, cells are cultured in 3D on a paper scaffold by adding a hydrogel precursor, as a fluid containing suspended cells, to a paper support, allowing the cell-containing fluid to distribute through the paper by capillary wicking,…
DBD
- Christopher Petty
Investigators
- George Whitesides
- Ratmir Derda
- Anna Laromaine Sague
A system for the continuous directed evolution of biomolecules
Researchers in the laboratory of Professor David Liu have developed a platform that enables the continuous directed evolution of gene-encoded molecules that can be linked to protein production in E. coli. During phage-assisted continuous evolution…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Kevin Esvelt
- Jacob Carlson
- Ahmed Badran
Metabolic labeling and direct imaging of choline-containing phospholipids in vivo
A functional analog of a metabolic phospholipid precursor has been devised that, when contacted with cells, becomes incorporated into a cells endogenous phospholipids through cellular metabolic processes. The resulting phospholipids contain a moiety…
DBD
- Grant Zimmermann
Investigators
- Adrian Salic
Potent OGT inhibitors for the treatment of cancer and diabetic complications
First-in-class and potent OGT inhibitors The Walker group has developed novel high throughput assays (HTS) and screened 200,000 compounds at the Institute for Chemistry and Cell Biology (ICCB) at Harvard Medical School, and identified several…
DBD
- Vivian Berlin
Investigators
- Suzanne Walker Kahne
- Michael Lazarus
- Benjamin Gross
The SMALL Microscope: Scanning microscopy on a chip
Fresnel zone plates use extremely short focal lengths. The Crozier lab has demonstrated that an imaging system with a short focal length zone plate, in combination with a spatial filter formed by a relay lens, can provide a high collection…
DBD
- Sam Liss
Investigators
- Kenneth Crozier
- Ethan Schonbrun
Knockout mouse model for human liver cancer
While most hepatocytes in healthy liver are resting cells, deletion of Mad2 in liver activates the cell cycles and causes proliferation of hepatocytes. Cre-mediated, simultaneous liver-specific knockout of Mad2 and p53 induces mouse cancer which…
DBD
- Grant Zimmermann
Investigators
- Peter Sorger
- Ying Yue
Oligopaints as a means for marking chromosomes with superior resolution and labeling functionality
Oligopaints could provide a means for marking chromosomes with superior resolution and labeling functionality than currently commercially available chromosome paint alternatives. In addition, the technology may be applied to any organism for which…
DBD
- Maryanne Fenerjian
Investigators
- Chao-ting Wu
- George Church
- Benjamin Williams