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Displaying: 71 - 80 of 103 Results
Interaction-dependent PCR: Multiplexed identification of ligand-target pairs from DNA-encoded ligand/target libraries in a single solution-phase experiment
IDPCR is based on the melting temperature difference between duplex DNA formed intramolecularly versus intermolecularly. Binding of a target to its ligand would increase the effective molarity of single-stranded DNA oligonucleotides linked to the…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- David Gorin
- Adam Kamlet
- Lynn McGregor
- Christoph Dumelin
Analyzing trace gases at part-per-billion levels by rapid gas-phase cooling
This invention realizes a new idea of using buffer gas to rapidly cool small gas molecules to very low temperatures.
DBD
- Christopher Petty
Investigators
- John Doyle
- David Patterson
Materials presenting Notch signaling molecules to control cell behavior
This technology has direct application to stem cell therapy, regenerative medicine, and tissue engineering in vivo (in the patient) and in vitro (in tissue culture dish). -In vitro stem cell manipulation- Using this method of introducing Notch…
Investigators
- David Mooney
- Lan Cao
- Kamal Bouhadir
Novel lipid hormone for identifying and treating metabolic disease
Scientists in the Harvard School of Public Health have identified fatty acid C16:1n7-palmitoleate, a novel signaling lipid produced by adipose tissue, that protects mice from the detrimental effects of long-term consumption of high-fat diets. They…
DBD
- Vivian Berlin
Investigators
- Gokhan Hotamisligil
- Dariush Mozaffarian
- Haiming Cao
Induced motor neurons (iMNs)
The team converted mouse and human fibroblasts into iMNs by the forced expression of select transcription factors. Producing motor neurons this way is much less labor intensive than having to go through the process of creating induced pluripotent…
DBD
- Vivian Berlin
Investigators
- Kevin Eggan
- Justin Ichida
- Esther Son
- Brian Wainger
- Clifford Woolf
Cyborg tissue: Macroporous nanowire nanoelectronic scaffolds for synthetic tissues
This technology uses macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds. The structures…
DBD
- Christopher Petty
Investigators
- Charles Lieber
- Bozhi Tian
- Jia Liu
Measuring resistance at the scale of a single transistor
According to Moore’s law, electronic devices such as transistors have been shrinking in size to yield higher performance. Currently, feature sizes are on the order of 10 nm, and important parameters for the device operation, such as temperature and…
Investigators
- Mikhail Lukin
- Hongkun Park
Functionalized and coated carbon nanotubes via atomic layer deposition
Carbon nanotubes have remarkable electrical and optical properties that have not been extensively commercialized in part due to difficulties making robust and high quality devices containing them. One current difficulty is the lack of an effective…
DBD
- Christopher Petty
Investigators
- Roy Gordon
- Damon Farmer
- Charles Marcus
- James Williams
Long-range quantum communication based on solid-state photon emitters
Quantum communication holds promise for transmitting secure messages via quantum cryptography, as well as for distributing quantum information. However, attenuation in optical fibers fundamentally limits the range of direct quantum communication…
Investigators
- Mikhail Lukin
- Jacob Taylor
- Anders Sorensen
- Lilian Childress
Implanted silicon-vacancy centers with coherent optical properties as a quantum computing platform
Atom-like optical emitters in the solid state are a promising platform for future applications in quantum computing, secure communications, and magnetometry. This invention describes a method of using ion implantation to produce silicon-vacancy…
Investigators
- Mikhail Lukin
- Ruffin Evans
- Alp Sipahigil