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Nuclear Quadrupole Resonance Spectroscopy of a Two-Dimensional Material
The Lukin group's technology provides a way to characterize the properties of atomically-thin samples of 2D materials (e.g., hexagonal boron-nitride, graphene, transition metal dichalcogenides), using nuclear quadrupole resonance (NQR). NQR is a…
Investigators
- Mikhail Lukin
- Igor Lovchinsky
- Hongkun Park
Continuous directed evolution of aminoacyl-tRNA synthetases to alter amino acid specificity and enhance activity
DESCRIPTION Functions of various biotherapeutics can often be enhanced by modifying individual amino acid residues. However, the current approaches rely on existing natural amino acid chemistry. Approaches that provide new chemical “handles” will…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers
DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies featuring modified nucleic acid polymers. The Liu lab has previously developed pioneering methods to generate…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
Band-gap tunable elastic optical multilayer fibers
Soft photonic fibers that reflect light in the visible spectrum via microscopic multilayer arrangements. The technology is inspired by photonic structures encountered in nature that reflect light to produce vivid and brilliant colors. Key aspects of…
DBD
- Christopher Petty
Investigators
- Joanna Aizenberg
DNA methylation as a predictor of biological age
Reliable indicators of biological age, rather than chronological age, have been investigated for several decades without much success. Recent studies indicate that epigenetic clock is a reliable predictor of biological age, given its strong…
DBD
- Grant Zimmermann
Investigators
- Liming Liang
Compounds For Organic Light Emitting Diode Materials
Machine learning promises to radically reduce the cycle time for computational chemistry. This invention is a library of molecules novel deep blue molecule for use in OLED displays, which were identified through the use of machine learning. OLEDs…
DBD
- Sam Liss
Investigators
- Alan Aspuru-Guzik
- Rafael Gomez-Bombarelli
- Timothy Hirzel
- Jorge Aguilera-Iparraguirre
Novel platform for rapid, immunization-free nanobody discovery
This is a novel platform technology that can be used to expedite the development of nanobodies for therapeutic and diagnostic applications by avoiding the need for animal immunization.Nanobodies are single-domain antibodies derived from camelids…
DBD
- Grant Zimmermann
Investigators
- Andrew Kruse
Transmitter-receiver for terahertz communication based on a harmonically phase-locked quantum cascade laser
Wi-Fi and cellular data traffic are increasing exponentially but, unless the capacity of wireless links can be increased, all that traffic is bound to lead to unacceptable bottlenecks. Upcoming 5G networks are a temporary fix but not a long-term…
Investigators
- Federico Capasso
- Marco Piccardo
- Dmitry Kazakov
Novel antibiotics against Gram-negative and drug-resistant bacterial pathogens
Dr. Kahne has a pipeline of programs aimed at developing first-in-class antibiotics:Program I: Potentiator of polymixin, increasing its therapeutic index for treatment of drug-resistant infectionsIn vitro: Novel agent potentiates activity of…
DBD
- Vivian Berlin
Investigators
- Daniel Kahne
SIM-PAL: proteome wide identification of small molecule binding sites
Precise target identification for small molecules is an important and essential step in drug development. Despite its importance, there are very few unbiased, proteome-wide approaches aimed at identifying binding partners for small molecules. In…
DBD
- Grant Zimmermann
Investigators
- Christina Woo