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Displaying: 1-10 of 18 Results
A fragment based drug discovery platform for high-throughput synthesis and screening of protein-protein inhibitors
The present invention enables generation of a large number of rigid compounds that incorporate one or more protein binding fragments in a…
Investigators:
Gerhard Wagner
Patrick Hagner
Haribabu Arthanari
Vladimir Gelev
Ricard Rodriguez-Mias
Amr Fahmy
Case #: 4717A system for in vivo generation of protective CD8+ T lymphocytes and other cells of hematopoietic origin
Differentiated CD8+ effector T cells mediate long-term immunity and protection against infectious diseases and cancer. Naive T cells are…
Investigators:
Arlene Sharpe
Nicholas Haining
Case #: 5821Altered specificity proteases that cleave and inactivate IL-23
SummaryIL-23 (interleukin 23) is a cytokine that is known to play a major role in the immune system and the development of…
Investigators:
David Liu
Case #: 6670Bisphosphonates as novel adjuvants to enhance the adaptive immune response, validated with common types of vaccine antigens and commercial vaccines
Despite decades of adjuvant research, only a handful of adjuvants have been approved in seven major global markets and only two (Alum and…
Investigators:
Ulrich von Andrian
Matteo Iannacone
Elena Tonti
Elliott Moseman
Case #: 3845Cardiac glycosides as treatments for inflammatory and autoimmune diseases
Bufalin and other cardiac glycoside inhibitors of the sodium-potassium ATPase (sodium pump) potently inhibit the induction of the…
Investigators:
Thomas Maniatis
Junqiang Ye
Shuibing Chen
Case #: 3787CD1- mice developed in the laboratory of Dr. Michael Grusby
Homozygous Cd1tm1Gru knock-out mice (C.129S2-Cd1tm1Gru/J, also known as CD1-) were developed by Dr. Michael J. Grusby at Harvard…
Investigators:
Michael Grusby
Case #: HU3350Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers
DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies…
Investigators:
David Liu
Case #: 6849Homozygous IKKepsilon knockout mouse as an animal model for influenza virus infection
Homozygous IKKepsilon (inhibitor of kappaB kinase epsilon) mutant mice are used as animal models for influenza virus infection. Homozygous…
Investigators:
Thomas Maniatis
Benjamin tenOever
Case #: 2807Identification of Key Pathogenic Factor of Cancer Cachexia
Cancer cachexia is a wasting syndrome that involves the progressive loss of skeletal muscle and adipose tissue. This devastating syndrome…
Investigators:
Norbert Perrimone
Case #: 7107Immunology and Computational Biology Partnership
Professors Diane Mathis and Christophe Benoist at Harvard Medical School, together with other world-renowned immunologists and computational…
Investigators:
Diane Mathis
Christophe Benoist
Case #: