DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 11 - 20 of 75 Results
Invention
Animal model of diabetes and obesity
Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity.
Investigators
- Gokhan S. Hotamisligil
- Michael Karin
Invention
A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for recombination-mediated modulation of gene activity in the developing mouse embryo. Using the enhancer of the Wnt1 gene to…
Investigators
- Andrew P. McMahon
- Paul S. Danielian
- David H. Rowitch
Invention
Cell-based assay for the discovery of glycogen synthase kinase inhibitors
This cell-based assay is applicable to diverse biological systems for discovery of glycogen synthase kinase inhibitors. The inhibition of GSK-3b has dramatic morphogenic effects during the early development of numerous organisms, including humans,…
Investigators
- Douglas Melton
- Peter S. Klein
Invention
In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading to neural degeneration in ALS. A potential solution is to use embryonic stem cells (ESC) as a renewable…
Investigators
- Kevin Carl Eggan
- Francesco Paolo Di Giorgio
Invention
Ultra fast method for chiral catalyst discovery
This invention is a novel method for determining--in less than 24 hours--enantiomeric ratios, percent conversions, and absolute configurations of all members of a chemical library containing at least 10,000 reaction products. Reaction mixtures are…
Investigators
- Matthew D. Shair
- Gregory A. Korbel
- Gojko Lilac
Invention
Using (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage
• ILV can be used alone, or in combination with growth factors, to direct differentiation of ESCs into pancreatic specification. ILV is effective on human ESC lines and mouse ESC lines. • ILV is effective on human ESC lines HUES 2, 4 and 8. After 4…
Investigators
- Douglas Melton
- Shuibing Chen
- Malgorzata Borowiak
- Julia L. Fox
- Stuart L. Schreiber
- Lee F. Peng
- Lee L. Rubin
- Kelvin Lam
- Lance Davidow
Invention
A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research
This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and incorporated into nucleic acid by PCR for use in genomic research applications. One assay design involves a…
Investigators
- Gregory L. Verdine
- Michael J. Storek
Invention
Potent OGT inhibitors for the treatment of cancer and diabetic complications
First-in-class and potent OGT inhibitors The Walker group has developed novel high throughput assays (HTS) and screened 200,000 compounds at the Institute for Chemistry and Cell Biology (ICCB) at Harvard Medical School, and identified several…
Investigators
- Suzanne Walker Kahne
- Michael B Lazarus
- Benjamin J. Gross
Invention
Lead compounds for the treatment of pain
The invention is a novel synthetic pathway to the generation of nonpeptidic ligands for the mu opioid class of G-protein coupled receptors. The system uses stereochemical variation and acyclic geometric stereocontrol to generate diversity among its…
Investigators
- Gregory L. Verdine
- Bryce A. Harrison
- Tiffany Kaye Malinky Gierasch
- Zhangjie Shi
Invention
Novel lipid hormone for identifying and treating metabolic disease
Scientists in the Harvard School of Public Health have identified fatty acid C16:1n7-palmitoleate, a novel signaling lipid produced by adipose tissue, that protects mice from the detrimental effects of long-term consumption of high-fat diets. They…
Investigators
- Gokhan S. Hotamisligil
- Dariush Mozaffarian
- Haiming Cao