DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 31 - 40 of 75 Results
Research Tool
Ngn3/CreER Trangenic Mice
These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse neurogenin 3, Neurog3, promoter. The transgene insert contains a fusion product involving Cre recombinase and a mutant form of the mouse estrogen…
Investigators
- Douglas Melton
Research Tool
B6(D2)-Tg(CAG-Brainbow1.0)3 Transgenic Mice
These transgenic mice carry the Brainbow 1.0 cassette, incorporating dTomato, mCerulean, and EYFP, driven by the broadly-expressed CAG (CMV-chicken beta actin) promoter. These fluorescent markers are useful in tracing cell lineage. This strain, line…
Investigators
- Kevin Carl Eggan
Research Tool
Six2-GCE Targeted Mutation Mice
While heterozygous mice are viable and fertile with no reported abnormalities, homozygous mice die shortly after birth. The Six2GCE "knock-in" allele both abolishes Six2 gene function and expresses an eGFPCreERT2 fusion protein (EGFP and creERT2…
Investigators
- Andrew P. McMahon
Research Tool
Ihh Transgenic Mice
Mice heterozygous for this targeted mutation are viable and fertile. Homozygotes die from respiratory failure shortly after birth. Expression of the "knocked-in" lacZ gene is detected in a pattern similar to the endogenous transcript (in lung,…
Investigators
- Andrew P. McMahon
Research Tool
Wnt5 Knock Out Mice
Homozygous null mice have a perinatal lethal phenotype and do not survive long after birth due to respiratory failure. Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or…
Investigators
- Andrew P. McMahon
Research Tool
RosaGli1Flag c/c Transgenic Mice
These RosaGli1Flag c/c mice contain a floxed-neomycin resistance (neo) cassette and polyadenylation signal, cDNA encoding a FLAG-tagged GLI-Kruppel family member (Gli1) gene, an internal ribosome entry site (IRES), and a Venus yellow fluorescent…
Investigators
- Andrew P. McMahon
Research Tool
Disp1_2C Transgenic Mice
These mice possess loxP sites on either side of exon 2 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When used in conjunction…
Investigators
- Andrew P. McMahon
Research Tool
Upk3a-GCE Transgenic Mice
These transgenic mice express the eGFPCreERT2 (Enhanced Green Fluorescent Protein and cre/ESR1) fusion gene under the direction of the mouse Upk3a, uroplakin 3A, promoter. Transgene expression is detected in the bladder urothelium and ureters of…
Investigators
- Andrew P. McMahon
Research Tool
Noggin Knock Out Mice
Homozygous mice are born but die shortly after birth, exhibiting multiple defects, including an open neural tube, skeletal abnormalities, shortened body axis, and a small vestigial tail. Analysis of early gene expression has shown that the loss of…
Investigators
- Andrew P. McMahon
Research Tool
Uba6flox/flox Targeted Mutation Mice
These Uba6flox/flox mutant mice possess loxP sites flanking exons 16-17 of the ubiquitin-like modifier activating enzyme 6 (Uba6) gene. Uba6 (E1) is part of the ubiquitin proteasome system (UPS) which regulates protein homeostasis during…