Vivian Berlin

Executive Director, HMS

Displaying: 31 - 40 of 75 Results

Research Tool

Osr1GCE Knock In Mice

Homozygous mice die upon birth with multiple abnormalities of the heart and urogenital system (among other tissues). Heterozygous mice are viable and fertile. The Osr1eGFPCreERt2 (Osr1GCE) "knock-in" allele both abolishes Osr1 gene function and…

Investigators

  • Andrew P. McMahon

Research Tool

Pdx1-CreER Transgenic Mice

Pancreatic cells are derived from Pdx1 (pancreatic and duodenal homeobox 1)-expressing progenitors throughout embryogenesis. This conditional transgenic strain expresses Cre/Esr1 from the mouse Pdx1 promoter. Cytoplasmic stores of Cre recombinase…

Investigators

  • Douglas Melton

Research Tool

Six2-GCE Targeted Mutation Mice

While heterozygous mice are viable and fertile with no reported abnormalities, homozygous mice die shortly after birth. The Six2GCE "knock-in" allele both abolishes Six2 gene function and expresses an eGFPCreERT2 fusion protein (EGFP and creERT2…

Investigators

  • Andrew P. McMahon

Research Tool

Hoxb7-cre Transgenic Mice

Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygotes are not viable. These transgenic mice express the Cre recombinase under the control of the…

Investigators

  • Andrew P. McMahon

Research Tool

Wnt3a Knock Out Mice

Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and, with the exception of a kinked tail, do not display any gross physical or behavioral abnormalities. Homozygous null mice have an embryonic lethal…

Investigators

  • Andrew P. McMahon

Research Tool

Osx1-GFP::Cre Transgenic Mice

Mice hemizygous for this Osx1-GFP::Cre transgene are viable and fertile. The transgene carries both tTA under the regulation of the osterix (Sp7) promoter and, just downstream, a tetracycline responsive element (TRE; tetO)-controlled GFP/Cre fusion…

Investigators

  • Andrew P. McMahon

Research Tool

Akr1b7RFP Trangenic Mice

These transgenic mice express Red Fluorescent Protein (TagRFP-T variant) under the direction of the mouse Akr1b7, aldo-keto reductase family 1, member B7, promoter. Transgene expression is detected at high levels in the adrenal glands and…

Investigators

  • Andrew P. McMahon

Research Tool

Six2-TGCtg EFGPCre Transgenic Mice

Six2-TGCtg mice harbor an ~181 kb BAC transgene with a Tet-off-eGFPCre under control of the Six2 promoter/enhancer regions within the BAC transgene. The Tet-off-eGFPCre contains both the tetracycline-controlled transactivator protein (tTA) as well…

Investigators

  • Andrew P. McMahon

Research Tool

Ihh Knock Out Mice

Mice that are heterozygous for the targeted allele are viable and fertile. Mice homozygous for this mutation have a lethal phenotype. Half of homozygous null mice have an embryonic lethal phenotype, dying between 10.5 to 12.5 days post coitum. The…

Investigators

  • Andrew P. McMahon

Research Tool

Wnt4 Knock Out Mice

Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous null mice have a perinatal lethal phenotype and die within 24 hours of birth.…

Investigators

  • Andrew P. McMahon

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