DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 31 - 40 of 75 Results
Research Tool
Cited1-nuc-TagRFP-T Transgenic Mice
These transgenic mice express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Cited1, Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1, promoter. TagRFP is the optimized monomeric…
Investigators
- Andrew P. McMahon
Research Tool
Sox2Cre Transgenic Mice
These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. The transgene integrated into an intron of Edil3 (EGF-like repeats and discoidin I-like domains 3). The insertion results in a…
Investigators
- Andrew P. McMahon
Research Tool
L7Cre Transgenic Mice
Hemizygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Cre activity is observed in parasagittal domains of the cerebellum beginning at embryonic day 17 (E17). At E19, low level…
Investigators
- Andrew P. McMahon
Research Tool
Wnt7bc3 LoxP Targeted Mutation Mice
Mice homozygous for the Wnt7bc3 allele are viable and fertile, with loxP sites flanking exon 3 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing…
Investigators
- Douglas Melton
Research Tool
Shh Knock Out Mice
Mice homozygous for the Shhtm1Amc targeted mutation display early defects in the establishment and maintenance of midline structures. These defects result from the critical role the Sonic hedgehog (Shh) gene plays in the patterning of vertebrate…
Investigators
- Andrew P. McMahon
Research Tool
gene trap ROSA 26 Targeted Mutation Mice
These mice contain a sequence encoding an intracellular portion of the mouse Notch1 gene (amino acids 1749-2293), but lacking the c-terminal PEST domain, and Green Fluorescent Protein, GFP, inserted into the GT(ROSA)26Sor locus. Expression of the…
Investigators
- Douglas Melton
Research Tool
Wnt11-myrTagRFP-IRES-CE Transgenic Mice
These Wnt11-myrTagRFP-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Wnt11, wingless-related MMTV integration site 11,…
Investigators
- Andrew P. McMahon
Research Tool
Pax4-cre Transgenic Mice
Pax4-cre transgenic mice have the mouse paired box gene 4 (Pax4) promoter directing expression of an enhanced green fluorescent protein fused to a Tet-off cassette (EGFP/tTA). The transgene also contains a tetracycline-responsive element with a CMV…
Investigators
- Douglas Melton
Research Tool
Cldn6CIHV Targeted Mutation Mice
In this strain, the Cldn6CIHV allele replaces the entire coding region of the claudin 6 (Cldn6) locus with a CreERT2 fusion protein, an internal ribosome entry site (IRES), and a histone H2B-Venus fluorescent protein. This abolishes gene expression.…
Investigators
- Douglas Melton
Research Tool
Sox2-cre Transgenic Mice
The Sox2Cre transgene was designed with 12.5 kb of upstream regulatory sequence from the mouse Sox2 locus (SRY-box containing gene 2), a chicken _-actin intron, a Cre recombinase gene, and a rabbit _-globin poly(A) sequence. This transgene was…
Investigators
- Andrew P. McMahon