Vivian Berlin

Executive Director, HMS

Displaying: 31 - 40 of 75 Results

Research Tool

Shh::gfp Targeted Mutation Mice

While mice heterozygous for the Shh::gfp allele are viable, fertile, and indistinguishable from wild-type littermates, homozygotes are stillborn and show developmental defects consistent with reduced Sonic Hedgehog (Shh) signaling. The Shh::gfp…

Investigators

  • Andrew P. McMahon

Research Tool

Ihh Knock Out Mice

Mice that are heterozygous for the targeted allele are viable and fertile. Mice homozygous for this mutation have a lethal phenotype. Half of homozygous null mice have an embryonic lethal phenotype, dying between 10.5 to 12.5 days post coitum. The…

Investigators

  • Andrew P. McMahon

Research Tool

Wnt4 Knock Out Mice

Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous null mice have a perinatal lethal phenotype and die within 24 hours of birth.…

Investigators

  • Andrew P. McMahon

Research Tool

Rosa26-rtTA::Col1a1-tetO-H2B-mCherry Targeted Mutation Mice

The Rosa26-rtTA::Col1a1-tetO-H2B-mCherry double mutant mice were generated by breeding Rosa26-rtTA mice (from Stock No. 006965) with Col1a1-tetO-H2B-mCherry mice (from Stock No. 014592). The Rosa26-rtTA targeted mutation has an optimized form of…

Investigators

  • Kevin Carl Eggan

Research Tool

Dhh Knock Out mice

Mice that are homozygous for the targeted mutation are viable, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous male mice are sterile due to arrested spermatogenesis at the late meiosis, primary…

Investigators

  • Andrew P. McMahon

Research Tool

Tshz3-GC eGFPCre Transgemic Mice

These transgenic mice express the eGFPCre (Enhanced Green Fluorescent Protein and Cre recombinase), GC, fusion gene under the direction of the mouse Tshz3, teashirt zinc finger family member 3, promoter. GFP fluorescence is detected in smooth muscle…

Investigators

  • Andrew P. McMahon

Research Tool

Ngn3/CreER Trangenic Mice

These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse neurogenin 3, Neurog3, promoter. The transgene insert contains a fusion product involving Cre recombinase and a mutant form of the mouse estrogen…

Investigators

  • Douglas Melton

Research Tool

B6(D2)-Tg(CAG-Brainbow1.0)3 Transgenic Mice

These transgenic mice carry the Brainbow 1.0 cassette, incorporating dTomato, mCerulean, and EYFP, driven by the broadly-expressed CAG (CMV-chicken beta actin) promoter. These fluorescent markers are useful in tracing cell lineage. This strain, line…

Investigators

  • Kevin Carl Eggan

Research Tool

Six2-GCE Targeted Mutation Mice

While heterozygous mice are viable and fertile with no reported abnormalities, homozygous mice die shortly after birth. The Six2GCE "knock-in" allele both abolishes Six2 gene function and expresses an eGFPCreERT2 fusion protein (EGFP and creERT2…

Investigators

  • Andrew P. McMahon

Research Tool

Ihh Transgenic Mice

Mice heterozygous for this targeted mutation are viable and fertile. Homozygotes die from respiratory failure shortly after birth. Expression of the "knocked-in" lacZ gene is detected in a pattern similar to the endogenous transcript (in lung,…

Investigators

  • Andrew P. McMahon

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