DBD Search
Grant R. Zimmermann
Managing Director of Business Development, Blavatnik Biomedical Accelerator
Displaying: 61 - 68 of 68 Results
Research Tool
Crx GFPAP Transgenic Mice
Hemizygotes are viable and fertile. Expression of human placental alkaline phosphatase (PLAP) and GFP recapitulates that of the endogenous Crx promoter in the retina at embryonic time points as early as embryonic day 12.5 (E12.5) and in the retina…
Investigators
- Connie Cepko
Research Tool
casp-11 Knock Out Mice
Caspase 4 (also known as caspase 11) is a critical upstream regulator in the caspase cascade with an important dual role in regulating both inflammatory response and apoptosis. Splenocytes harvested from homozygous mice both before and after…
Investigators
- Junying Yuan
Research Tool
Shh (EGFP/cre) Transgenic Mice
This strain expresses a fusion product involving Enhanced Green Fluorescent Protein (EGFP) and Cre recombinase from the endogenous Shh locus. EGFP and cre expression are consistent with the endogenous gene. Fluorescence is detected in the distal…
Research Tool
Crx Knock Out Mice
Homozygotes are viable and fertile and do not display any gross physical abnormalities. These mice do not elaborate photoreceptor outer segments and synaptic termini, and they lack cone and rod activities as assayed by electroretinograms. Circadian…
Investigators
- Connie Cepko
Research Tool
ACTB:FLPe B6N Transgenic Mice
This transgenic strain expresses a variant of the Saccharomyces cerevisiae FLP1 recombinase gene under the direction of the human ACTB promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being…
Investigators
- Susan M. Dymecki
Research Tool
Top2beta Flox2 Targeted Mutation Mice
These mice possess loxP sites flanking the 3 exons encoding the active-site tyrosyl residue of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral…
Investigators
- James Wang
Research Tool
Glar2 Knock Out Mice
Mice homozygous for this targeted mutation are viable and fertile and do not display any gross physical or behavioral abnormalities. There is no identifiable phenotype in these mice. Expression is eliminated in the brain as determined by RT-PCR and…
Investigators
- Connie Cepko
Research Tool
ACTB:FLPe Transgenic Mice
This transgenic strain expresses a variant of the Saccharomyces cerevisiae FLP1 recombinase gene under the direction of the human ACTB promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being…
Investigators
- Susan M. Dymecki