Grant R. Zimmermann

Managing Director of Business Development, Blavatnik Biomedical Accelerator

Displaying: 61 - 67 of 67 Results

Research Tool

R26:FRAP Knock In Mice

These mice possess a disrupted human placental alkaline phosphatase (ALPP) transgene inserted into the Gt(ROSA)26Sor locus. Expression of the ALPP transgene is contingent upon Flp-mediated excision of the FRT-flanked STOP cassette placed between the…

Investigators

  • Susan M. Dymecki

Research Tool

Caspase 2 Knock Out Mice

Mice homozygous for this caspase-2 targeted mutation are viable and fertile. As the mutation deletes the QACRG active site and the caspase-2S sequence of the endogenous enzyme, this deletion was shown to inactivate both the long and short form of…

Investigators

  • Junying Yuan

Research Tool

Ppp3ca Knock Out Mice

Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) is a calcium- and calmodulin-dependent serine/threonine protein phosphatase. It is an important signaling molecule in T cells, neurons, the heart, and kidneys. The catalytic domain of…

Research Tool

ROSA26::FLPe Knock In Mice

Homozygous FLPeR mice are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase variant exhibits enhanced thermostability…

Investigators

  • Susan M. Dymecki

Research Tool

Chx10-EGFP/cre,-ALPP Transgenic Mice

Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The transgene insert contains a fusion product involving Cre recombinase and an Enhanced Green…

Investigators

  • Connie Cepko

Research Tool

tetO-Gata6 Transgenic Mice

Gata6 Tg mice express GATA binding protein 6 (Gata6) cDNA under control of a tetracycline operator (tetO). Hemizygotes are viable and fertile. GATA6 is a zinc-finger-containing transcription factor involved in the regulation of early axial…

Research Tool

ROSA26::FLPe knock-in Targeted Mutation

Mice homozygous for the R26Fki knock-in allele (FLPeR mice) are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase…

Investigators

  • Susan M. Dymecki

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