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Invention

The next generation of cholesterol screening - A personalized diagnostic index for the improved assessment of cardiovascular risk using a novel method for the measurement of lipoprotein subtypes

OpportunityThis program offers the next generation of cholesterol screening. In 2013, 96 million visits to doctors' offices in the US included a cholesterol test.Problem/Unmet needCurrent practice of measuring total HDL level in serum does not…

Invention

Knockout mouse model for human liver cancer

While most hepatocytes in healthy liver are resting cells, deletion of Mad2 in liver activates the cell cycles and causes proliferation of hepatocytes. Cre-mediated, simultaneous liver-specific knockout of Mad2 and p53 induces mouse cancer which…

Invention

Monoclonal IgE anti-ovalbumin antibody

A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the level of IgE anti-ovalbumin antibodies in mouse models of…

Invention

Phaeobacticides - Potent and selective new class of algae growth inhibitors

Algae are a diverse group of uni- and multicellular plants that grow in water. Undesired and uncontrolled algal blooms are a recurring problem in bodies of water such as swimming pools, aquaculture ponds, aquariums, industrial drainage systems and…

Invention

SpeedGene: A compression algorithm for fast and efficient storage of next-generation genetic sequencing studies

To solve the problem of large file sizes and long loading times of pedigree files for GWAS studies and next-generation sequencing studies, researchers at the Harvard School of Public Health have developed a new compression algorithm -- SpeedGene –…

Invention

Protein-based therapies using quantitatively designed proteins

A bipartite, quantitatively designed protein having two discrete ligands and a linker; one ligand having the ability to strongly bind to a particular cell, the other having the ability to affect a target only when the previous ligand binds. For many…

Invention

Disease incidence/prevalence analytical model

Invention

HEK293T cells stably express Divalent Metal Transporter-1 for use in a model system to screen for inhibitors of iron uptake

This invention is a cell-based screen that enables the rapid identification of iron transport inhibitors. From initial efforts, 10 small molecule inhibitors of transport have been identified, and ongoing studies focus on characterizing their…

Invention

Migration inhibitory factor (MIF) knockout mouse

To study the biological role of migration inhibitory factor (MIF), a pleiotropic cytokine, we generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of the role of MIF during sepsis showed that MIF-/- mice were…