DBD Search
Grant R. Zimmermann
Managing Director of Business Development, Blavatnik Biomedical Accelerator
Displaying: 51 - 60 of 68 Results
Research Tool
casp-11 Knock Out Mice
Caspase 4 (also known as caspase 11) is a critical upstream regulator in the caspase cascade with an important dual role in regulating both inflammatory response and apoptosis. Splenocytes harvested from homozygous mice both before and after…
Investigators
- Junying Yuan
Research Tool
PDGFRa-CRE Transgenic Mice
Hemizygous Pdgfra-cre mice are viable and fertile, with cre expression directed to retinal Muller glial cells by the mouse Pdgfra (platelet derived growth factor receptor, alpha polypeptide) promoter. Expression is predominantly in the cell bodies…
Investigators
- Connie Cepko
Research Tool
R26:FRAP Knock In Mice
These mice possess a disrupted human placental alkaline phosphatase (ALPP) transgene inserted into the Gt(ROSA)26Sor locus. Expression of the ALPP transgene is contingent upon Flp-mediated excision of the FRT-flanked STOP cassette placed between the…
Investigators
- Susan M. Dymecki
Research Tool
ROSA26::FLPe Knock In Mice
Homozygous FLPeR mice are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase variant exhibits enhanced thermostability…
Investigators
- Susan M. Dymecki
Research Tool
ACTB:FLPe B6N Transgenic Mice
This transgenic strain expresses a variant of the Saccharomyces cerevisiae FLP1 recombinase gene under the direction of the human ACTB promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being…
Investigators
- Susan M. Dymecki
Research Tool
ROSA26::FLPe knock-in Targeted Mutation
Mice homozygous for the R26Fki knock-in allele (FLPeR mice) are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase…
Investigators
- Susan M. Dymecki
Research Tool
ACTB:FLPe Transgenic Mice
This transgenic strain expresses a variant of the Saccharomyces cerevisiae FLP1 recombinase gene under the direction of the human ACTB promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being…
Investigators
- Susan M. Dymecki
Research Tool
Shh (EGFP/cre) Transgenic Mice
This strain expresses a fusion product involving Enhanced Green Fluorescent Protein (EGFP) and Cre recombinase from the endogenous Shh locus. EGFP and cre expression are consistent with the endogenous gene. Fluorescence is detected in the distal…
Research Tool
Arrb1 Knock Out Mice
Mice homozygous for this Arrb1 (arrestin, beta 1) targeted mutation produce a cardiac ejection fraction that is greater than that of wildtype mice in response to isoproterenol, a _-receptor agonist. They are viable and fertile and do not display any…
Research Tool
Top2beta Flox2 Targeted Mutation Mice
These mice possess loxP sites flanking the 3 exons encoding the active-site tyrosyl residue of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral…
Investigators
- James Wang