DBD Search
Grant R. Zimmermann
Managing Director of Business Development, Blavatnik Biomedical Accelerator
Displaying: 51 - 60 of 68 Results
Research Tool
PDGFRa-CRE Transgenic Mice
Hemizygous Pdgfra-cre mice are viable and fertile, with cre expression directed to retinal Muller glial cells by the mouse Pdgfra (platelet derived growth factor receptor, alpha polypeptide) promoter. Expression is predominantly in the cell bodies…
Investigators
- Connie Cepko
Research Tool
Arrb1 Knock Out Mice
Mice homozygous for this Arrb1 (arrestin, beta 1) targeted mutation produce a cardiac ejection fraction that is greater than that of wildtype mice in response to isoproterenol, a _-receptor agonist. They are viable and fertile and do not display any…
Research Tool
Prg4GFPCreERt2 Transgenic Mice
The Prg4, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein), gene encodes the lubricin protein, a large proteoglycan that acts as a lubricant at the surface of cartilage of articulating joints. Prg4 also encodes…
Research Tool
R26:FRAP Knock In Mice
These mice possess a disrupted human placental alkaline phosphatase (ALPP) transgene inserted into the Gt(ROSA)26Sor locus. Expression of the ALPP transgene is contingent upon Flp-mediated excision of the FRT-flanked STOP cassette placed between the…
Investigators
- Susan M. Dymecki
Research Tool
Caspase 2 Knock Out Mice
Mice homozygous for this caspase-2 targeted mutation are viable and fertile. As the mutation deletes the QACRG active site and the caspase-2S sequence of the endogenous enzyme, this deletion was shown to inactivate both the long and short form of…
Investigators
- Junying Yuan
Research Tool
Ppp3ca Knock Out Mice
Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) is a calcium- and calmodulin-dependent serine/threonine protein phosphatase. It is an important signaling molecule in T cells, neurons, the heart, and kidneys. The catalytic domain of…
Research Tool
ROSA26::FLPe Knock In Mice
Homozygous FLPeR mice are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase variant exhibits enhanced thermostability…
Investigators
- Susan M. Dymecki
Research Tool
Chx10-EGFP/cre,-ALPP Transgenic Mice
Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The transgene insert contains a fusion product involving Cre recombinase and an Enhanced Green…
Investigators
- Connie Cepko
Research Tool
tetO-Gata6 Transgenic Mice
Gata6 Tg mice express GATA binding protein 6 (Gata6) cDNA under control of a tetracycline operator (tetO). Hemizygotes are viable and fertile. GATA6 is a zinc-finger-containing transcription factor involved in the regulation of early axial…
Research Tool
ROSA26::FLPe knock-in Targeted Mutation
Mice homozygous for the R26Fki knock-in allele (FLPeR mice) are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase…
Investigators
- Susan M. Dymecki