Grant R. Zimmermann

Managing Director of Business Development, Blavatnik Biomedical Accelerator

Displaying: 51 - 60 of 68 Results

Research Tool

Top2beta Flox2 Targeted Mutation Mice

These mice possess loxP sites flanking the 3 exons encoding the active-site tyrosyl residue of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral…

Investigators

  • James Wang

Research Tool

Glar2 Knock Out Mice

Mice homozygous for this targeted mutation are viable and fertile and do not display any gross physical or behavioral abnormalities. There is no identifiable phenotype in these mice. Expression is eliminated in the brain as determined by RT-PCR and…

Investigators

  • Connie Cepko

Research Tool

ACTB:FLPe Transgenic Mice

This transgenic strain expresses a variant of the Saccharomyces cerevisiae FLP1 recombinase gene under the direction of the human ACTB promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being…

Investigators

  • Susan M. Dymecki

Research Tool

UBC GFP TVA Transgemic Mice

UBC is a polyubiquitin precursor responsible for the regulation of cell signaling pathways upon conjugation with various proteins. The cTVA transgene in this strain carries the human ubiquitin C (UBC) promoter/enhancer elements driving expression of…

Investigators

  • Connie Cepko

Research Tool

PDGFRa-CRE Transgenic Mice

Hemizygous Pdgfra-cre mice are viable and fertile, with cre expression directed to retinal Muller glial cells by the mouse Pdgfra (platelet derived growth factor receptor, alpha polypeptide) promoter. Expression is predominantly in the cell bodies…

Investigators

  • Connie Cepko

Research Tool

Arrb1 Knock Out Mice

Mice homozygous for this Arrb1 (arrestin, beta 1) targeted mutation produce a cardiac ejection fraction that is greater than that of wildtype mice in response to isoproterenol, a _-receptor agonist. They are viable and fertile and do not display any…

Research Tool

Prg4GFPCreERt2 Transgenic Mice

The Prg4, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein), gene encodes the lubricin protein, a large proteoglycan that acts as a lubricant at the surface of cartilage of articulating joints. Prg4 also encodes…

Research Tool

R26:FRAP Knock In Mice

These mice possess a disrupted human placental alkaline phosphatase (ALPP) transgene inserted into the Gt(ROSA)26Sor locus. Expression of the ALPP transgene is contingent upon Flp-mediated excision of the FRT-flanked STOP cassette placed between the…

Investigators

  • Susan M. Dymecki

Research Tool

Caspase 2 Knock Out Mice

Mice homozygous for this caspase-2 targeted mutation are viable and fertile. As the mutation deletes the QACRG active site and the caspase-2S sequence of the endogenous enzyme, this deletion was shown to inactivate both the long and short form of…

Investigators

  • Junying Yuan

Research Tool

Ppp3ca Knock Out Mice

Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) is a calcium- and calmodulin-dependent serine/threonine protein phosphatase. It is an important signaling molecule in T cells, neurons, the heart, and kidneys. The catalytic domain of…

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