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DBD Search
Grant R. Zimmermann
Managing Director of Business Development, Blavatnik Biomedical Accelerator
Displaying: 21 - 30 of 68 Results
Invention
“TRUC mice” Tbx21-/-.Rag2-/- (BALB/c) mice developed by Dr. Laurie Glimcher
Homozygous T-bet-/- × RAG2-/- deficient mice were created in the laboratory of Dr. Glimcher at Harvard University. These mice develop a spontaneous jevenille ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota…
Invention
CDK5R1/p25 transgenic mice developed in the laboratory of Dr. Li-Huei Tsai
Hemizygous CDK5R1 transgenic mice (C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J, also known as p25 Tg) were developed in the laboratory of a former HHMI investigator Dr. Li-Huei Tsai at Harvard University. The mice express CDK5R1/GFP fusion protein under the…
Invention
Studying interactions between essential bacterial ABC (ATP-binding cassette) transporter MsbA and bacterial LPS to pave the way for new antibiotic discovery
Gram-negative bacteria cause multiple infectious disease and are increasingly becoming resistant to antibiotics. However, development of drugs targeting these organisms is complicated by the extreme complexity of the structure of gram-negative cell…
Investigators
- Maofu Liao
Invention
Novel Antifungal Agent
The existing suite of clinically useful antifungals is limited. While amphotericin B and nystatin have been used widely over the past 50 years, they are associated with high toxicity and negligible oral bioavailability. Harvard researchers in the…
Investigators
- Jon Clardy
Invention
Selectively targeting serotonergic neuron subtypes to create precision neuro-psychiatric therapeutics
Targeting central monoamine systems, such as the brain serotonergic neural system, continues to be the strategy of choice for the treatment of psychiatric disorders including depression and schizophrenia. Selective serotonin reuptake inhibitors…
Investigators
- Susan M. Dymecki
Invention
Antibody Target and Biomarker for Oocytes and Egg Quality Profiling
Harvard researchers have identified a way to isolate and manipulate oogonial stem cells (OSCs) with greater efficacy and validity than current methods. OSCs facilitate oocyte production in the ovary and serve as a foundation for promising new…
Investigators
- David Sinclair
Invention
Microbiome reagents to treat inflammatory bowel disease and restore gut homeostasis
Reactive oxygen species (ROS) and oxidative stress are believed to cause and/or aggravate several diseases, including inflammatory diseases like inflammatory bowel disease (IBD). Antioxidants have the ability to neutralize the damaging effects of…
Investigators
- Wendy Garrett
Invention
Innovative microbiome anti-oxidants to repair UV damaged skin and slow aging
Ultraviolet (UV) radiation from the sun drives accumulation of reactive oxygen species (ROS) and inflammation in the skin. UV radiation also depletes skin cells of antioxidant enzymes, including superoxide dismutase (SOD). Increased ROS and…
Investigators
- Wendy Garrett
Invention
Environmentally Safe, First-in-Class Mosquito Sterilant
Dr. Flaminia Catteruccia from the Harvard T.H. Chan School of Public Health has discovered a biopesticide that is capable of sterilizing mosquitoes while being safe for human and environmental health. Spraying pesticides is a common method to…
Investigators
- Flaminia Catteruccia
Invention
Novel therapies for neural regeneration
Researchers at the Flanagan lab discovered a novel therapeutic approach for stimulation of neuronal regeneration. They demonstrated that type II receptor protein tyrosine phosphatases (RPTPs) get activated by several heparan sulfate proteoglycans…
Investigators
- John G. Flanagan
- Yingjie Shen
- Alan Peter Tenney
- Jerry Silver