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Utilizing the herpes simplex virus-based vaccine vectors to develop a COVID-19 vaccine
Researchers in the lab of David Knipe have constructed the HSV-1 based vaccine vector HSV-1 d106S. The vector can express viral, bacterial, or cancer gene products and has been used to induce protective immunity in humanized mice against HIV and…
DBD
- Vivian Berlin
Investigators
- David Knipe
Machine learning to accelerate diagnostics and therapeutics for COVID-19
The COVID-19 pandemic demands a rapid response of science, diagnostics, and therapeutics. Debora Marks’ lab at Harvard Medical School aims to accelerate those efforts using predictive models of the SARS-CoV2-19 sequences and 3D structures. The lab’s…
DBD
- Irit Ben-Chelouche
Investigators
- Debora Marks
Novel adjuvants to enhance adaptive immune response of vaccines
Researchers in the lab of Ulrich von Andrian have discovered a novel adjuvanting behavior of a clinically approved and well-tolerated class of medicines known as bisphosphonates. The team is hoping to collaborate with manufacturers of COVID-19…
DBD
- Irit Ben-Chelouche
Investigators
- Ulrich von Andrian
Self-adjuvanting mRNA platform technology
Researchers in the lab of Prof. George Church at Harvard Medical School have developed a vaccine platform technology that can be applied to fields such as infectious diseases and oncology therapeutics. The team is looking to further demonstrate…
DBD
- Grant Zimmermann
Investigators
- George Church
Stick-on Large-Strain Sensors for Soft Robots
Soft robots require sensors that are soft, stretchable, and conformable to preserve their adaptivity and safety. This technology provides “stick-on” large-strain sensors for soft robots and enables novel functionality for wearable robots, serving as…
DBD
- Sam Liss
Investigators
- Robert Howe
- Zhigang Suo
- Canhui Yang
- Sibo Cheng
- Yashraj Narang
Compounds that block human cytomegalovirus by targeting the nuclear egress complex
Researchers in Dr. Donald Coen’s lab have identified molecules that inhibit human cytomegalovirus (HCMV) virion egress from the cell, effectively inhibiting HCMV replication. The team is looking to expand on these findings in collaborations that…
DBD
- Grant Zimmermann
Investigators
- Donald Coen
Cancer Treatment through TRPA1 antagonism
Researchers in Joan Brugge’s lab have identified a new cancer therapeutic target in the ion channel transient receptor potential ankyrin 1 (TRPA1). The lab is seeking collaborations with industry partners to expand on these exciting findings. The…
DBD
- Grant Zimmermann
Investigators
- Joan Brugge
Membrane protein nanoparticles for antigen presentation
Researchers in the lab of Dr. James Chou have engineered a new way to display membrane proteins to enhance vaccine immunogenicity using functionalized nanoparticles. The lab has successfully displayed several viral peptides using this technique and…
DBD
- Grant Zimmermann
Investigators
- James Chou
Graphene device for terahertz wave generation - opportunities for next gen medical imaging
Terahertz (THz) waves are a desirable source for non-invasive imaging for medical and security purposes, as they are non-ionizing and do not damage tissues. However, generation of THz radiation is significantly more challenging than generating…
Investigators
- Mikhail Lukin
- Bo Dwyer
- Trond Andersen
- Javier Sanchez-Yamagishi
- Hongkun Park
- Philip Kim
- Eugene Demler
- Kartiek Agarwal
Integrated mounting solution for solid state spin sensors used for bulk detection and imaging
Sensors based on solid state spin system for measuring magnetic fields, electric fields, temperature, pressure, and other physical quantities can offer high resolution sensing at low cost and low power input. These systems employ point defects in…
Investigators
- Ronald Walsworth
- Matthew Turner
- John Barry
- Jennifer Schloss