DBD Search
Grant R. Zimmermann
Managing Director of Business Development, Blavatnik Biomedical Accelerator
Displaying: 11 - 20 of 68 Results
Invention
Digital DNA Storage System
A startup emerging from George Church's lab intends to leverage new enzymatic approaches to develop a cost-effective digital DNA storage system. (Image credit: Shutterstock/Chornyi Serhii.)The volume of global digital information is growing…
Investigators
- George M. Church
Invention
DNA methylation as a predictor of biological age
Reliable indicators of biological age, rather than chronological age, have been investigated for several decades without much success. Recent studies indicate that epigenetic clock is a reliable predictor of biological age, given its strong…
Investigators
- Liming Liang
Invention
Novel platform for rapid, immunization-free nanobody discovery
This is a novel platform technology that can be used to expedite the development of nanobodies for therapeutic and diagnostic applications by avoiding the need for animal immunization.Nanobodies are single-domain antibodies derived from camelids…
Investigators
- Andrew Kruse
Invention
SIM-PAL: proteome wide identification of small molecule binding sites
Precise target identification for small molecules is an important and essential step in drug development. Despite its importance, there are very few unbiased, proteome-wide approaches aimed at identifying binding partners for small molecules. In…
Investigators
- Christina Woo
Invention
Polycystic Kidney Disease: Mechanistic Dissection and Discovering Precision Therapeutic Targets
Autosomal-dominant polycystic kidney disease (ADPKD) is a life-threatening monogenic disease that affects nearly 1 million people in the U.S. alone. ADPKD represents a very large unmet medical need, currently without remedy. It is characterized by…
Investigators
- Adrian Salic
Invention
Glp1r-ires-Cre (Glp1r-ires-Cre knock-in mice)
Glp1r (Glucagon-Like Peptide 1 Receptor) -ires-Cre knock-in mice were developed in Dr. Stephen Liberles lab at Harvard Medical School. IRES and Cre sequence were inserted after the gene Glp1r, thus the mouse strain expresses Cre recombinase in cells…
Investigators
- Stephen D. Liberles
Invention
Gpr65-ires-Cre (Gpr65-ires-Cre knock-in mice)
Gpr65 (G Protein-Coupled Receptor 65) -ires-Cre knock-in mice were developed by Dr. Stephen Liberles and members of his lab at Harvard Medical School. In these mice, expression of Cre recombinase is controlled by Gpr65 promoter in Gpr65-positive…
Investigators
- Stephen D. Liberles
Invention
CD1- mice developed in the laboratory of Dr. Michael Grusby
Homozygous Cd1tm1Gru knock-out mice (C.129S2-Cd1tm1Gru/J, also known as CD1-) were developed by Dr. Michael J. Grusby at Harvard University. The mutant mice are deficient in both the Cd1.1 and Cd1.2 genes, and lack the normal natural killer…
Investigators
- Michael J. Grusby
Invention
B6.Cg-Shhtm1(EGFP/cre)Cjt/J mice developed in the laboratory of Dr. Clifford Tabin
This mouse stain, also known as Shhgfpcre was originally described in Cell in 2004. The mice express GFP in all cell expressing Shh, and specifically, in the distal posterior region of the limb buds of embryos aged embryonic day 10 to 12. Mice…
Investigators
- Clifford Tabin
Invention
ROSA26 FLPeR mice developed in the laboratory of Dr. Susan Dymecki
Homozygous FLPe knock-in mice (B6N.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/J, also known as ROSA26::FLPe knock in) were developed by Dr. Susan Dymecki using ROSA26 segments provided by Dr. Phillippe Soriano. The mouse strain carries the FLPe knock-in allele…
Investigators
- Susan M. Dymecki