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B6.Cg-Shhtm1(EGFP/cre)Cjt/J mice developed in the laboratory of Dr. Clifford Tabin
This mouse stain, also known as Shhgfpcre was originally described in Cell in 2004. The mice express GFP in all cell expressing Shh, and specifically, in the distal posterior region of the limb buds of embryos aged embryonic day 10 to 12. Mice…
DBD
- Grant Zimmermann
Investigators
- Clifford Tabin
ROSA26 FLPeR mice developed in the laboratory of Dr. Susan Dymecki
Homozygous FLPe knock-in mice (B6N.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/J, also known as ROSA26::FLPe knock in) were developed by Dr. Susan Dymecki using ROSA26 segments provided by Dr. Phillippe Soriano. The mouse strain carries the FLPe knock-in allele…
DBD
- Grant Zimmermann
Investigators
- Susan Dymecki
“TRUC mice” Tbx21-/-.Rag2-/- (BALB/c) mice developed by Dr. Laurie Glimcher
Homozygous T-bet-/- × RAG2-/- deficient mice were created in the laboratory of Dr. Glimcher at Harvard University. These mice develop a spontaneous jevenille ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota…
DBD
- Grant Zimmermann
CDK5R1/p25 transgenic mice developed in the laboratory of Dr. Li-Huei Tsai
Hemizygous CDK5R1 transgenic mice (C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J, also known as p25 Tg) were developed in the laboratory of a former HHMI investigator Dr. Li-Huei Tsai at Harvard University. The mice express CDK5R1/GFP fusion protein under the…
DBD
- Grant Zimmermann
Trpa1 conditional knockout mice
The mouse strain 129S-Trpa1tm2Kykw/J was developed by Kelvin Kwan in the laboratory of HHMI Investigator David Corey at Harvard Medical School. Trpa1 conditional knockout animals were generated by flanking the exons that code for the pore domain of…
DBD
- Irit Ben-Chelouche
Investigators
- Kelvin Kwan
- David Corey
TRPA1 knockout mice developed in the laboratory of Professor David Corey
Homozygous Transient Receptor Potential Cation Channel Subfamily A Member 1 (TRPA1) mutant mice (B6;129P-Trpa1tm1Kykw/J, also known as Trpa1 KO) were developed by HHMI Investigator David Corey at Harvard Medical School. They exhibit abnormal…
DBD
- Irit Ben-Chelouche
Investigators
- David Corey
Studying interactions between essential bacterial ABC (ATP-binding cassette) transporter MsbA and bacterial LPS to pave the way for new antibiotic discovery
Gram-negative bacteria cause multiple infectious disease and are increasingly becoming resistant to antibiotics. However, development of drugs targeting these organisms is complicated by the extreme complexity of the structure of gram-negative cell…
DBD
- Grant Zimmermann
Investigators
- Maofu Liao
Compact, tunable lens using compliant transparent electrodes
Conventional lenses have specific focal lengths and aberration characteristics due to their shape and comprising material. For adaptable systems, such as a camera that can focus at objects at different distances, often mechanical systems area used…
DBD
- Christopher Petty
Investigators
- David Clarke
- Samuel Shian
- Roger Diebold
High speed 3D magnetometry using NV centers in diamond
Many magnetic field sensing applications including orienting and stabilizing aircraft and down-hole drilling machines, as well as field imaging, require the determination of the magnetic field projection along all three spatial directions (X, Y, and…
Investigators
- Ronald Walsworth
- John Barry
- Jennifer Schloss
- Matthew Turner
- Mikael Backland
Measuring resistance at the scale of a single transistor
According to Moore’s law, electronic devices such as transistors have been shrinking in size to yield higher performance. Currently, feature sizes are on the order of 10 nm, and important parameters for the device operation, such as temperature and…
Investigators
- Mikhail Lukin
- Hongkun Park